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Residues of cellulose and breakdown products in edible tissues and products from animals fed HPMC are not expected. Although the (partial) degradation of HPMC would eventually occur in some species (ruminants, hindgut fermenters), breakdown products would still likely be of high molecular weight and poorly or not absorbed; the short-chain fatty acids resulting from microbial breakdown of cellulose in the rumen or hindgut will enter the physiological pools of the animals. The consumer would therefore not be exposed to the additive or derived products when consuming edible tissues and products from animals given diets containing HPMC. Consequently, the FEEDAP Panel concludes that the use of HPMC in animal nutrition is of no concern for consumer safety.

The etherification of cellulose disrupts the hydrogen bonding and the resulting compounds are not ionised and more water soluble. The EFSA ANS Panel (2018) concluded that modified celluloses including ethyl and methyl, hydroxypropyl celluloses, would not be absorbed intact and not fermented in the gastrointestinal tract of animals (rat) or humans; they are excreted essentially unchanged mainly via the faeces (more than 90% of the administrated doses), while only minor amounts of metabolites and derived-products are excreted via urine or expired air (as ¹⁴CO₂) and there is no indication for accumulation in the body.